Earlier, Tottenham hammered Leeds 4-0 to keep their hopes alive of qualifying for next season's Champions League while Burnley earned a point in a 1-1 draw at Crystal Palace.
Brentford boss Thomas Frank brought on Denmark playmaker Eriksen in the 52nd minute with his side trailing 2-0 at home to Newcastle after goals from Joelinton and Joseph Willock. It was the first appearance in a competitive match for the 30-year-old former Tottenham and Inter Milan playmaker since he collapsed on the pitch during Denmark's opening Euro 2020 match against Finland in June.
Eriksen has been fitted with a implantable cardioverter defibrillator but was unable to continue his career with Italian champions Inter, with ICDs not permitted in Serie A. The midfielder was given a standing ovation by the crowd and both sets of players at the Brentford Community Stadium as he made his entrance. But he was unable to influence the scoreline, with Newcastle's 2-0 win lifting them above Brentford, who are now just three points above the relegation zone.
Crystal Palace took an early lead against Burnley through Jeffrey Schlupp but the visitors were level shortly after half-time after a Luka Milivojevic own goal.
Aston Villa's match at Brighton kicked off late due to traffic issues around the Amex stadium. Matty Cash put Villa in front in the first half and lifted his shirt to reveal a message to Poland international team-mate Tomasz Kedziora, who plays his club football for Dynamo Kyiv in Ukraine. Then, Ollie Watkins got the second in a 0-2 win.
Everton host leaders Manchester City in the late-kick off.