Matches Last 16 - US Open Cup 2022

End

Last 16

Orlando City

1 (4-2) 1

Inter Miami

26 MAY 2022

End

Last 16

Louisville City

1-2

Nashville SC

26 MAY 2022

End

Last 16

New York City

1-0

New England Revolution

26 MAY 2022

End

Last 16

New York RB

3-1

Charlotte FC

26 MAY 2022

End

Last 16

Minnesota United

1-2

Union Omaha

26 MAY 2022

End

Last 16

Sporting Kansas City

2-1

Houston Dynamo

26 MAY 2022

End

Last 16

LA Galaxy

3-1

Los Angeles FC

26 MAY 2022

End

Last 16

Sacramento Republic

2-0

San Jose Earthquakes

26 MAY 2022