Both sides have league fixtures to negotiate before they can focus wholeheartedly on their European commitment, which could cause problems for either manager as they try to get their best XI ready for the Bernabeu on Wednesday.
Zinedine Zidane's selection headache has been made perfectly clear, however, his French opposition could face a similar predicament as injuries strike his players on the lead-up to their Ligue 1 game against Toulouse on Saturday.
Firstly, Edinson Cavani has been omitted from PSG's squad for the trip to the south of France and appears to be fighting against the clock to be fit in time for the crunch match against Madrid.
In addition, left-back Layvin Kurzawa suffered a muscle cramp in his right thigh in Friday's training session and may have to settle for a place on the bench for both games.
It could see Yuri Berchiche be given the nod to start against the Spanish giants and the defender has plenty of experience playing against his European opposition thanks to his spell in La Liga with Real Sociedad.
The 28-year-old has alternated the left-back position with Kurzawa all season, with both players offering different attributes for Emery in the team.
Yuri does not have the same offensive threat as his French team-mate, however, he would be a more defensively solid choice which could be extremely important over the two-legged tie, especially as the first is being played away from the Parc des Princes.
Speaking in the build-up to the clash, Emery has expressed his confidence in whoever he chooses at left-back: "I have confidence in both of them. Yuri is also ready, but I will not say who will play on Wednesday [until nearer the time]".
However, with Kurzawa facing fitness concerns so close to the start of the match, it could lead to a surprise inclusion for Yuri in front of the Bernabeu crowd.