While the spotlight might be on Arsenal v Manchester United, there's plenty more to digest in this week's fixtures:
Everton v Wolves
At Goodison Park, Everton and Wolves face off in what could prove to be a crucial battle in the fight for Premier League survival. Both sides find themselves perilously close to the relegation zone, making this midweek clash a true six-pointer.
Sean Dyche’s Toffees will be counting on their home crowd for a boost, while Wolves, under Gary O’Neil, hope to capitalise on their recent flashes of resilience.
Everton starting XI: Jordan Pickford (GK); Ashley Young, Tarkowski, Branthwaite, Mykolenko; Idrissa Gueye, Doucoure, Mangala; Dwight McNeil, Calvert-Lewin and Ndiaye.
Wolves starting XI: Jose Sa (GK); Ait-Nouri, Craig Dawson, Santoi Bueno, Doherty; Joao Gomes, Mario Lemina, Andre; Goncalo Guedes, Larsen and Matheus Cunha.
Manchester City v Nottingham Forest
Pep Guardiola's side are in unfamiliar territory, having gone five matches without a win in all competitions, including four defeats and a draw. Their form has raised eyebrows, but the visit of Nottingham Forest might provide a chance for redemption.
Forest, however, come into this clash brimming with confidence after winning three of their last five matches and losing only two. Can City find their rhythm again, or will Forest add to their misery?
Manchester City starting XI: Ortega Moreno (GK); Manuel Akanji, Ruben Dias, Nathan Ake, Josko Gvardiol; Gundogan, De Bruyne, Bernardo Silva; Jeremy Doku, Jack Grealish and Erling Haaland.
Nottingham Forest starting XI: Matz Sels (GK); Alex Moreno, Murillo, Milenkovic, Ola Aina; Dominguez, Gibbs-White, Ryan Yates; Jota Silva, Chris Wood and Elanga.
Newcastle v Liverpool
Premier League leaders Liverpool head to St James' Park with their eyes firmly set on extending their nine-point cushion over second-placed Arsenal. Arne Slot's side are flying high, but Newcastle will look to upset the balance with their resolute home form.
The Magpies, known for their intensity and tactical discipline, are unlikely to make life easy for the Reds.
Newcastle starting XI: Nick Pope (GK); Tino Livramento, Fabian Schar, Dan Burn, Lewis Hall; Sandro Tonali, Guimaraes, Joelinton; Jacob Murphy, Alexander Isak and Anthony Gordon.
Liverpool starting XI: Kelleher (GK); Robertson, Van Dijk, Joe Gomez, Jarell Quansah; Mac Allister, Curtis Jones, Gravenberch; Cody Gakpo, Darwin Nunez and Salah.
Southampton v Chelsea
Enzo Maresca's Chelsea have been revitalised under the Italian manager, and their trip to St Mary's could offer another opportunity to showcase their resurgence.
With key players finding form and confidence on the rise, the Blues will aim for a win to maintain their momentum. Southampton, however, can be unpredictable, and their home advantage could prove challenging for the visitors.
Southampton starting XI: Joe Lumley (GK); Kyle Walker-Peters, James Bree, Nathan Wood, Jack Stephens, Ryan Manning; Joe Aribo, Mateus Fernandes; Armstrong, Cameron Archer and Ryan Fraser.
Chelsea starting XI: Jorgensen (GK); Cucurella, Adarabioyo, Axel Disasi, Malo Gusto; Fernandez, Cole Palmer, Caicedo; Joao Felix, Nkunku and Madueke.
Aston Villa v Brentford
Unai Emery's Aston Villa will be desperate to halt their recent slide in form. A series of disappointing results have seen the Villans lose ground but they'll be keen to bounce back at Villa Park. Brentford, though, are no pushovers, and their well-organised approach could make this an evenly contested affair.
Aston Villa starting XI: Emiliano Martinez (GK); Matty Cash, Konsa, Mings, Lucas Digne; Kamara, Morgan Rogers, Tielemans; Leon Bailey, Ollie Watkins and McGinn.
Brentford starting XI: Mark Flekken (GK); Lewis-Potter, Pinnock, Nathan Collins, Van den Berg; Vitaly Janelt, Damsgaard, Yarmolyuk; Kevin Schade, Yoane Wissa and Bryan Mbeumo.
Arsenal v Manchester United
Arsenal's clash with Manchester United is undeniably the headline act of this midweek round. With both teams battling to establish their credentials in the upper echelons of the table, this encounter promises fireworks.
Who will take centre stage in this midweek drama? Time will tell, but the action is set to deliver thrills, surprises, and all the twists that make the Premier League the most exciting league in the world.
Arsenal starting XI: Raya (GK); Timber, Saliba, Kiwior, Zinchenko; Odegaard, Thomas Partey, Rice; Saka, Havertz and Martinelli.
Manchester United starting XI: Onana (GK); Maguire, De Ligt, Mazraoui; Malacia, Dalot; Bruno Fernandes, Ugarte; Garnacho, Hojlund and Mount.