Pep Guardiola's side are once again on the brink of securing the title after an impressive performance in beating Tottenham Hotspur 3-1 at Wembley on Saturday.
Gabriel Jesus and Raheem Sterling scored for City either side of an Ilkay Gundogan penalty as they bounced back in style from the disappointment of their Champions League quarter-final exit at the hands of Liverpool in midweek.
It had been a traumatic week for City, who threw away a two-goal interval lead to lose 3-2 at home to United in the derby last weekend, missing the chance to become champions in front of their own fans at the Etihad Stadium.
However, City are now 16 points clear of second-placed United, meaning a defeat for Jose Mourinho's men at Old Trafford against a West Brom side on the brink of relegation -- kick-off is at 15:00 GMT -- would wrap up a third title in seven seasons.
A draw in that game would effectively confirm City as champions as well -- it would leave United 15 points behind with five games remaining, while Guardiola's side also boast a far superior goal difference.
Nonetheless, a United victory on Sunday afternoon would keep City's champagne on ice for a few more days at least.
But a 'Red Devils' defeat against Bournemouth in midweek or a City win over Swansea City next Sunday would wrap up the silverware.