United are many people's favourities to progress to the quarter-final of the European competition, but that doesn't mean their Spanish opposition should be approached lightly. Within their arsenal are five players who, on their day, could destroy anyone.
Jesus Navas
He may have only scored two goals this season, but that is because the former Manchester City has been converted into an attacking right-back. Within his new-found position, it allows the Spaniard to make deadly runs down the wing to become an endless source of crosses and through balls for his team-mates, which United will have to deal with.
Ever Banega
Despite doubts over his fitness, it appears the midfielder will be available for the game which will be a massive boost for Sevilla. No player has completed more Champions League passes than his 711 as his touch and vision will look to pull apart the United defence and midfield on Wednesday.
Luis Muriel
The 26-year-old striker has blossomed since the arrival of Vincenzo Montella and although he hasn't started a Champions League game yet, he may be given the nod against United to contend with their physical centre-backs. In 19 league appearances, he's scored five and provided one assist.
Pablo Sarabia
The Spaniard has more La Liga assists than any other Sevilla player this season and will be looking to add to his tally on Wednesday. Quick, intelligent, disciplined, reliable and dangerous when coming inside, he will be a handful for United's defence.
Wissam Ben Yedder
Although it is unclear who will start between Yedder and his strike partner Muriel, the 27-year-old would be a brilliant impact substitute. He's Sevilla's top goalscorer this season with 17 goals from 30 games in all competitions and would be the likely bet to pop up with a winner at the death.