The game marks Pogba's return to the squad having missed the FA Cup victory over Huddersfield through illness.
'Red Devils' manager Jose Mourinho had suggested that Pogba was available for selection against the Andalusian outfit, only to opt for a midfield three of Nemanja Matic, Ander Herrera and Scott McTominay.
The omission will no doubt lead to further question marks about the relationship between Mourinho and Pogba, despite the Portuguese previously having dismissed talk of a rift as "lies".
Elsewhere, Ashley Young gets the nod a left-back whilst Victor Lindelof is given another chance to shine at centre-back.
United's team for the game is as follows:
21 February 2018