The Londoners are on a sorry run of form in the Premier League, having failed to win in their last four games, picking up just two points in the process.
That return has left them trailing leaders Manchester City by some 18 points, as well as giving them a four-point deficit to the top four.
However, the Champions League has been a happier hunting ground for Spurs so far this campaign, with Pochettino's side winning their group after taking four points off holders Real Madrid and the Argentine is hoping that Wednesday's game can be used to give his side a much-needed boost ahead of their Premier League tests to come.
"No, I'm not worried because the performances were good," Pochettino said ahead of the game. "We are frustrated because the results are not good but it's not about the performances.
"I cannot complain about the effort or many things, only that for different reasons we have struggled to get good results in the last few games.
"We are focused on this game because it's so important to win, important to finish the Champions League well and it's so important to build our momentum again.
"As a team, we need to build another good moment and it's a good opportunity to play well and only by winning games we are going to build again our momentum."
The former Southampton boss also confirmed that Dele Alli would start the game against APOEL, but that there would be a significant amount of rotation as Pochettino looks to share out the workload.
"Yes we are going to rest some players," Pochettino admitted. "Of course we are going to rotate the starting XI but Dele is going to play because he missed three Champions League games and I think he needs to play and he's fresh to play.
"Always in football you never know when is the right opportunity to rotate or give opportunities for players to play because when you win you can stop the momentum if you rest players and when you don't win, like on Saturday [against Watford], maybe you should give the possibility to the same players to play and build the momentum.
"I think always it's important to assess the players and be sure that some players need to rest because they are so tired and they need to breathe a little bit.
"It's a game that only provides us with the opportunity to play with some players that need to be ready if we need them. Then it's a great opportunity to show to the gaffer and the fans that they are available to play and can be regularly in the starting XI.
"We need to take the game very seriously because we want to win and try to build our momentum. We have a lot of games ahead and some players need to rest."