Scholes began his tenure with a 4-1 win over Yeovil Town, but three draws and three defeats followed, leaving Oldham in 14th, the same position they were in when he started. Scholes made it clear that he would be leaving due to interference from the board.
"It unfortunately became clear that I would not be able to operate as I intended and was led to believe prior to taking on the role," he said.
"I hoped to at the very least, see out my initial term of 18 months as the manager of a club I've supported all my life."
"The fans, players, my friends and family all knew how proud and excited I was to take this role. I wish the fans, the players and the staff - who have been tremendous - all the best for the rest of the season and will continue to watch and support the club as a fan."