Plateau United are currently 3 points clear of closest challengers Lobi Stars, who are away to Akwa United at the weekend.
Bottom side Nasarawa United will be hoping to add to their 5 points but they have a tricky match away to MFM FC. Adamawa United can move outside the relegation zone if they beat Rivers United, and Warri Wolves fail to beat Kwara United and/or Jigawa Golden Stars fail to beat Katsina United. Likewise Kwara United can move out the relegation zone if results go their way.
In the other matches, Ifeanyi Ubah are at home to Heartland and Sunshine Stars welcome Dakkada.
Enugu Rangers v Kano Pillars and Enyimba v Wikki Tourists FC have been rearranged due to Enugu Rangers' and Enyimba's participation in the CAF Confederation Cup.
On Thursday bottom-placed Nasarawa United are at home to Kano Pillars.