The Portuguese midfielder, who has over 110 caps for his country, received the ball on the edge of the area from Raul Jimenez.
Taking little time to set himself, Moutinho curled one into the postage stamp.
David De Gea was rooted to the spot, and could only watch the ball fly past him.
Joao Moutinho has played six games for Wolves, with this being his first goal. He has also garnered an assist.
September 22, 2018