The hosts were already two goals to the good following strikes from Mohamed Salah and a stunner from Alex Oxlade-Chamberlain when Mane took centre stage.
Salah was fed the ball down the right and when his attempted show was cleared, he was the first to react, latching onto the loose ball.
This time, the Egyptian opted to cross and his ball in was perfect for Mane, who had peeled off Vincent Kompany at the far post to head home and leave City stunned.
Check out the strike for yourself below:
April 4, 2018