Wayne Rooney will face his ex-team Manchester United after Deby won 4-2 at home to Northampton. A young Liverpool side were victorious against Shrewsbury and they have set up a last 16 tie away to Chelsea.
Birmingham won on penalties after a 2-2 draw with Coventry and will play away to Leicester in the next round. Reading also won on penalties against Cardiff and will entertain Sheffield United.
Newcastle are away to West Brom after winning 3-2 away to Oxford, while the winner of Tottenham and Southampton will play at home to Norwich.
FA Cup 5th round draw:
Sheffield Wednesday vs Manchester City
Reading vs Sheffield United
Chelsea vs Liverpool
West Bromwich Albion vs Newcastle United
Leicester City vs Birmingham
Derby County vs Manchester United
Southampton or Tottenham Hostpur vs Norwich City
Portsmouth vs Arsenal