The match will take place at the 82,000-seat home of Borussia Dortmund on March 23, three days after the first leg at Milan's San Siro.
In a statement, DFB sporting director Rudi Voeller said: "Dortmund is the perfect location for what is a football classic."
Germany, who are in the Nations League knockouts for the first time, won their most recent game at the venue, a 2-0 victory over Denmark in the Euro 2024 quarter-finals.
Unlike England's Wembley and the Stade de France in Paris, Germany does not have a national football stadium, with games shared around the federal nation.
December 12, 2024