The 31-year-old Sierra Leone striker, who topped the MLS goal charts this season with 22, leaped into the air and made an awkward landing.
A Twitter posting from the Crew said Kamara suffered a "right leg knock" and his status will not be determined until match time.
"My guess right now is he would be available," Crew coach Gregg Berhalter said, adding, "I wouldn't put a player at risk. That's not my style. That's not our style of the club."
Berhalter admitted the Crew would have to change its game plan without talisman Kamara in the lineup.
"It would change. The top goalscorer in the league would not be playing in this game so it would affect us," Berhalter said. "We would have to regroup, come up with another idea, another plan and try to execute it."