The likes of Claudio Bravo, Phil Foden, Yaya Toure and Gabriel Jesus all came into the side as Ederson, Kevin De Bruyne and Sergio Aguero were dropped to the bench, with David Silva rested completely.
In total there were six changes to the team that beat Chelsea 1-0 at the weekend, with John Stones and Danilo the other incomings, with Vincent Kompany and Kyle Walker also rested.
The experienced Yaya Toure will captain the side as City look to make their way into the quarter-finals off the back of a victory.
There was also a smattering of City's top young talent on the bench with Brahim Diaz and Tosin Adarabioyo among Pep Guardiola's options later in the game.
7 March 2018
Basel meanwhile line up as follows:
7 March 2018