At Stamford Bridge, Chelsea won 4-3 on penalties after a 1-1 draw against Aston Villa. Much-maligned German forward Timo Werner headed Chelsea into the lead in the 54th minute, finishing off Reece James' cross for his first goal in 11 games. With Villa fan Prince William watching from the stands, 19-year-old striker Cameron Archer equalised in the 64th minute with a close-range header from Matty Cash's cross.
James scored Chelsea's winning penalty in the shoot-out after Ashley Young and Marvelous Nakamba missed for Villa.
Harry Kane ended his goal drought as Tottenham boss Nuno Espirito Santo knocked out his former club Wolves 3-2 on penalties after a 2-2 draw at Molineux. Tanguy Ndombele gave Tottenham a 14th-minute lead when he charged down Conor Coady's clearance and shot past John Ruddy. Kane, without a goal in his four previous games, increased Tottenham's advantage after 23 minutes. Dele Alli's perfect pass sent Kane clear and the England captain found the bottom corner.
Leander Dendoncker pulled one back for Wolves seven minutes before the break when he headed in Rayan Ait-Nouri's corner. Daniel Podence levelled 13 minutes into the second half from Dendoncker's pass.
In the shootout, Dendoncker, Ruben Neves and Coady all missed for Wolves.
Arsenal eased to a 3-0 win against third tier AFC Wimbledon at the Emirates Stadium. The Gunners, featuring 10 changes from the weekend win at Burnley, went ahead in the 11th minute. Gabriel Martinelli was fouled by Nesta Guinness-Walker and Alexandre Lacazette slotted home the penalty. Emile Smith-Rowe doubled the lead in the 77th minute and Eddie Nketiah's impudent flick wrapped up the win three minutes later.
Ademola Lookman scored his first Leicester goal in a 2-0 win at second tier Millwall. Lookman, making his maiden Leicester start following his loan move from RB Leipzig, netted five minutes into the second half with a cool strike after Kelechi Iheanacho's effort was saved by George Long. Iheanacho got on the scoresheet himself, driving into the roof of the net in the 88th minute.
Brighton manager Graham Potter enjoyed a 2-0 win against his former club Swansea thanks to a first half brace from Aaron Connolly at the Amex Stadium.